One of the main reasons alcohol is not recommended with Cenforce 150 mg is because alcohol can interfere with the blood flow that Sildenafil aims to enhance. While Sildenafil works by inhibiting the enzyme PDE5, which promotes smooth muscle relaxation and increases blood flow to the penis, alcohol can have the opposite effect. It can dilate blood vessels and cause dehydration, reducing the body’s ability to maintain healthy blood flow. This can result in lowered erectile function, making it harder for a man to achieve or maintain an erection, even when taking the medication. As a result, alcohol consumption can render Cenforce 150 mg less effective, leading to disappointment or frustration during sexual activity.